23181
Chloromethyl chloroformate
≥98.0% (GC)
동의어(들):
1-Chloromethyl chloroformate, Chloroformic acid chloromethyl ester, Chloromethoxycarbonyl chloride, Chloromethyl carbonochloridate, Chloromethyl chlorocarbonate
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모든 사진(1)
About This Item
Linear Formula:
ClCOOCH2Cl
CAS Number:
Molecular Weight:
128.94
Beilstein:
506426
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
Quality Level
분석
≥98.0% (GC)
형태
liquid
refractive index
n20/D 1.428
bp
107-108 °C (lit.)
density
1.450 g/mL at 20 °C
작용기
chloro
저장 온도
2-8°C
SMILES string
ClCOC(Cl)=O
InChI
1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
InChI key
JYWJULGYGOLCGW-UHFFFAOYSA-N
애플리케이션
Chloromethyl chloroformate was used as key reactant in the synthesis of:
- novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid
- highly water-soluble monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A
- series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Inhalation - Skin Corr. 1B
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
203.0 °F - closed cup
Flash Point (°C)
95 °C - closed cup
개인 보호 장비
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
이미 열람한 고객
Lina Ribeiro et al.
Archiv der Pharmazie, 340(1), 32-40 (2007-01-09)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid
E Carvalho et al.
Bioorganic & medicinal chemistry, 8(7), 1719-1725 (2000-09-08)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis
Hoon Cho et al.
Archives of pharmacal research, 27(6), 662-669 (2004-07-31)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to
Keivan Sadrerafi et al.
Drug design, development and therapy, 12, 987-995 (2018-05-08)
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is a promising target for the treatment of many different types
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