902527

Amino-PEG5-t-butyl ester

≥95%

• 동의어(들): tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H₂N-PEG₅-CH₂CH₂COOtBu
• 실험식(Hill 표기법): C₁₇H₃₅NO₇
• CAS Number: 1446282-18-3
• Molecular Weight: 365.46
• MDL number: MFCD25424125
• UNSPSC 코드: 51171641

속성

• 분석: ≥95%
• 형태: liquid
• 반응 적합성: reagent type: cross-linking reagent
• refractive index: n/D 1.4534
• density: 1.4690 g/mL
• 작용기: amine; ester
• 저장 온도: −20°C
• SMILES string: NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): No data available
• Flash Point (°C): No data available