700121P

sitostanol

β-sitostanol, powder

• 동의어(들): stigmastanol; dihydrositosterol; (3β)-stigmastan-3-ol; (3β,5α)-stigmastan-3-ol
• 실험식(Hill 표기법): C₂₉H₅₂O
• CAS Number: 83-45-4
• Molecular Weight: 416.72
• MDL number: MFCD11109453
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 5 mg (700121P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 700121P
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: O[C@@H]1C[C@H]2[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](C(C)C)CC)C)(CC3)C)CC2)(CC1)C
• InChI: 1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
• InChI key: LGJMUZUPVCAVPU-HRJGVYIJSA-N

설명

일반 설명

It is predominantly present in pine oil.

Sitostanol is a 5α-saturated sitosterol derivative.

Sitostanol is a plant stanol and a hydrogenated form of sitosterol.

애플리케이션

Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.

Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).

생화학적/생리학적 작용

Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.

Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.

Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.

포장

5 mL Amber Glass Screw Cap Vial (700121P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids