A-071

Alfentanil hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₂₁H₃₃ClN₆O₃
• CAS Number: 69049-06-5
• Molecular Weight: 452.98
• MDL number: MFCD00941457
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329770623
• NACRES: NA.24

속성

• Grade: certified reference material
• Quality Level: 300
• 양식: liquid
• 특징: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• 농도: 1.0 mg/mL in methanol (as free base)
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: forensics and toxicology
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: CCN(N=N1)C(N1CCC2CCC(N(C3=CC=CC=C3)C(CC)=O)(COC)CC2)=O.Cl
• InChI: 1S/C21H32N6O3.ClH/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26;/h6-10H,4-5,11-17H2,1-3H3;1H
• InChI key: AQORHZJDCHLLJN-UHFFFAOYSA-N
• 유전자 정보: human ... OPRM1(4988)

설명

일반 설명

A Snap-N-Spike^® Reference Solution suitable as starting material for use in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing and pharmaceutical research. Alfentanil is a pharmaceutical synthetic opioid sold as Alfenta and Rapifen for pain relief and anesthesia.

애플리케이션

• Highly sensitive electrochemical detection: Research has developed a promising electrochemical platform for detecting fentanyl and alfentanil in human serum, suggesting a highly sensitive method to monitor these potent analgesics in clinical settings (Li et al., 2023).


• Pharmacodynamic analysis under anesthesia: A study compared the effects of electromyogram to bispectral index and 95% spectral edge frequency under remimazolam and propofol anesthesia, which could be relevant for alfentanil usage scenarios in surgical settings (Xin et al., 2023).


• Opioid-sparing anesthesia: A propensity score matching cohort study demonstrated that dexmedetomidine provides stable hemodynamics and short hospital stays in non-intubated thoracoscopic surgery, applicable for integrating alfentanil as part of opioid-sparing strategies (Ke et al., 2023).


• Response to opioid supply shortages: Discussion on potential responses to remifentanil supply shortages, highlighting alternative strategies including the use of alfentanil, offers insights into managing opioid resources in healthcare (Sneyd, 2022).


• Vaccine development against synthetic opioids: A study on the preclinical efficacy and selectivity of vaccines targeting fentanyl, alfentanil, sufentanil, and acetylfentanyl suggests a novel approach to treating or preventing opioid abuse and overdose (Baehr et al., 2022).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup