추천 제품
Grade
certified reference material
Quality Level
양식
liquid
특징
Snap-N-Spike®/Snap-N-Shoot®
포장
ampule of 1 mL
제조업체/상표
Cerilliant®
농도
1.0 mg/mL in acetonitrile
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
clinical testing
pharmaceutical (small molecule)
형식
single component solution
저장 온도
−20°C
SMILES string
[2H]C([2H])([2H])C(C(O)=O)C(O)=O
InChI
1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)/i1D3
InChI key
ZIYVHBGGAOATLY-FIBGUPNXSA-N
일반 설명
Methylmalonic acid, a malonic acid derivative, is a vital intermediate in the metabolism of fat and proteins and plays a key role in energy metabolism. Elevated methylmalonic acid levels can be caused by an inborn error of metabolism leading to methylmalonic aciduria or indicate early vitamin B<sub>12</sub> deficiency. This internal standard is suitable for quantitation of methylmalonic acid levels by LC/MS or GC/MS in newborn screening and clinical testing applications to test for methylmalonic acidemia and diagnose vitamin B<sub>12</sub> deficiency.
애플리케이션
- Assessment of Vitamin B-12 Status: Methyl-D3-malonic acid, as a deuterated derivative of malonic acid, was highlighted for its application in quantifying vitamin B-12 status using dried blood spots. This method provides a stable, precise measure and is useful in nutritional research and clinical diagnostics (Schroder et al., 2014).
- Improvement of Analytical Methods: Methyl-D3-malonic acid was used in a gas chromatography-mass spectrometry (GC-MS) technique to quantify methylmalonic acid in serum. This application underlines its role in improving diagnostic assays by offering enhanced precision and reliability in biochemical measurements (Straczek et al., 1993).
법적 정보
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
35.6 °F - closed cup
Flash Point (°C)
2 °C - closed cup
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