8.51088

TOTU

Novabiochem^®

• 동의어(들): TOTU, O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,NÆ,NÆ-tetramethyluronium tetrafluoroborate
• 실험식(Hill 표기법): C₁₀H₁₇BF₄N₄O₃
• CAS Number: 136849-72-4
• Molecular Weight: 328.07
• MDL number: MFCD00192127
• UNSPSC 코드: 12352116
• NACRES: NA.22

속성

• Quality Level: 200
• 제품 라인: Novabiochem^®
• 분석: ≥99.0% (HPLC)
• 양식: powder
• 효능: 500-650 mg/kg LD₅₀, oral (Rat)
• 반응 적합성: reaction type: Coupling Reactions
• 제조업체/상표: Novabiochem^®
• mp: 142-148 °C
• 응용 분야: peptide synthesis
• 저장 온도: 2-8°C
• SMILES string: [B-](F)(F)(F)F.N([C+](N(C)C)ON=C(C(=O)OCC)C#N)(C)C
• InChI: 1S/C10H17N4O3.BF4/c1-6-16-9(15)8(7-11)12-17-10(13(2)3)14(4)5;2-1(3,4)5/h6H2,1-5H3;/q+1;-1
• InChI key: FPQVGDGSRVMNMR-UHFFFAOYSA-N

설명

일반 설명

TOTU is an excellent alternative to HOBt-based coupling reagents such as HBTU and TBTU. It has high reactivity and is likely to have low allergenicity and low explosivity. The by-products of using this coupling reagent are water-soluble, making it an ideal choice for solution phase coupling reactions.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents


Literature references

^[1] G. Breipohl & W. Koenig, US patent 5166394.

분석 메모

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clear soluble

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302 - H317 - H318 - H335
• 예방조치 성명서: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1A - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable