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Merck
모든 사진(1)

주요 문서

PHR1011

Supelco

Ethylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Ethyl 4-hydroxybenzoate, EP, Ethylparaben

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About This Item

Linear Formula:
HOC6H4CO2C2H5
CAS Number:
Molecular Weight:
166.17
Beilstein:
1101972
EC Number:
MDL number:
UNSPSC 코드:
41116107
eCl@ss:
39024522
PubChem Substance ID:
E 번호:
E214
NACRES:
NA.24

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. E2425000
traceable to USP 1267000

API family

parabens

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

bp

297-298 °C (lit.)

mp

114-117 °C (lit.)

응용 분야

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

CCOC(=O)c1ccc(O)cc1

InChI

1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3

InChI key

NUVBSKCKDOMJSU-UHFFFAOYSA-N

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일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

애플리케이션

Ethylparaben may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

분석 메모

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAC3158 in the slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC
Shabir GA.
Journal of Pharmaceutical and Biomedical Analysis, 34(1), 207-213 (2004)
K L Pedersen et al.
Pharmacology & toxicology, 86(3), 110-113 (2001-02-07)
The widely used phenolic preservatives ethylparaben, propylparaben, butylparaben and their common metabolite p-hydroxybenzoic acid were tested for their ability to evoke an oestrogenic response in vivo. Yolk protein induction in sexually immature rainbow trout was used as an oestrogen-specific endpoint
S Nicoli et al.
Journal of pharmaceutical sciences, 97(11), 4830-4839 (2008-03-05)
This work aims at investigating the nicotinamide (NA)-ethyl-paraben (EP) binary system both in solution and in the solid state. In particular, the apparent EP solubility in water was studied in the presence of different NA concentrations (between 0.28 and 1.64
Sawsan El Hussein et al.
Experimental dermatology, 16(10), 830-836 (2007-09-12)
Concern is continuously raised about the safety of parabens which are present in most of the cosmetic preparations. In this investigation, methyl-, ethyl-, propyl- and butyl paraben (MP, EP, PP, BP), in a commercial cosmetic lotion, were deposited on human
Shinshi Oishi
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(11), 1845-1849 (2004-09-08)
Parabens are alkyl esters of p-hydroxybenzoic acid widely used as preservatives in foodstuffs, cosmetics toiletries and pharmaceuticals. These compounds are known to exert a weak estrogenic activity in estrogen receptor assays in vitro. In addition butyl and propyl parabens show

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