추천 제품
생물학적 소스
synthetic
Quality Level
결합
FITC conjugate
양식
powder or crystals
분자량
average mol wt 4,000
구성
carboxymethyl content, 3-7%
라벨링 범위
0.001-0.020 mol/mol FITC glucose
기술
permeability assay: suitable
형광
λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0
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일반 설명
FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.
애플리케이션
FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Stefanie J Anderson et al.
Comparative medicine, 69(1), 4-15 (2018-12-14)
Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycin and metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function, cytokine and chemokine profiles, and neutrophil migration in
Yuxin Leng et al.
PloS one, 9(10), e109350-e109350 (2014-10-09)
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Scientific reports, 6, 22814-22814 (2016-03-17)
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Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
문서
Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.
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