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Merck
모든 사진(1)

주요 문서

94072

Sigma-Aldrich

Phalloidin–Atto 565

suitable for fluorescence, ≥80.0% (HPLC)

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About This Item

UNSPSC 코드:
12352108
NACRES:
NA.32

Quality Level

분석

≥80.0% (HPLC)

형태

solid

분자량

Mw 1394 g/mol

제조업체/상표

ATTO-TEC GmbH

λ

in methanol

UV 흡수

λ: 562.0-568.0 nm Amax

적합성

suitable for fluorescence

저장 온도

−20°C

일반 설명

Atto 565 is a novel fluorescent label that belongs to the class of Rhodamine dyes. It shows a strong absorption, high fluorescence quantum yield, high thermal and photostability, and a very little triplet formation. Atto 565 consists of a mixture of two isomers with practically identical optical absorption and emission Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서

Atto dyes are a series of fluorescent dyes that meet the critical needs of modern fluorescent technologies.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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