A0737

N-acetylcysteine amide

≥98% (HPLC), lyophilized powder, antioxidant

• 동의어(들): (R)- 2-(Acetylamino)-3-mercapto-Propanamide, AD4, N-Acetyl-L-cysteinamide, NACA, acetylcysteinamide
• 실험식(Hill 표기법): C₅H₁₀N₂O₂S
• CAS Number: 38520-57-9
• Molecular Weight: 162.21
• MDL number: MFCD01696115
• UNSPSC 코드: 12352209
• PubChem Substance ID: 329770626
• NACRES: NA.25

속성

• product name: N-acetylcysteine amide, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: lyophilized powder
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: H₂O: ≥20 mg/mL; DMSO: >40 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CC(=O)N[C@@H](CS)C(N)=O
• InChI: 1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
• InChI key: UJCHIZDEQZMODR-BYPYZUCNSA-N

설명

애플리케이션

N-acetylcysteine amide has been used:

• to protect retinal pigment epithelium (RPE) from oxidative stress
• to show that increased expression of cell adhesion molecule 4 (CADM4) in oligodendrocytes inhibits myelination
• to protect cells from apoptosis induced by shikonin plus erlotinib/gefitinib
• as a component in various culture media

as an antioxidant to reduce oxidative stress in brains of homozygous Drosophila spermine synthase (dSms e/e) mutant flies and melanoma cells.

생화학적/생리학적 작용

N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

기타 정보

This product is hydroscopic and air sensitive.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable