A3230

AR-A014418

≥98% (HPLC), solid

• 동의어(들): N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea
• 실험식(Hill 표기법): C₁₂H₁₂N₄O₄S
• CAS Number: 487021-52-3
• Molecular Weight: 308.31
• MDL number: MFCD08277040
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329770820
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: off-white to tan
• solubility: DMSO: ≥20 mg/mL, clear, light yellow; H₂O: insoluble
• 주관자: AstraZeneca
• 저장 온도: 2-8°C
• SMILES string: COc1ccc(CNC(=O)Nc2ncc(s2)[N+]([O-])=O)cc1
• InChI: 1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
• InChI key: YAEMHJKFIIIULI-UHFFFAOYSA-N

설명

일반 설명

AR-A014418 may have chronic pain-relieving properties. In mice having neuropathic pain, this molecule has been shown to have antihyperalgesic effects. AR-A014418 may modulate proinflammatory cytokines and the catecholaminergic and serotonergic pathways. It has also been studied that AR-A014418 inhibits growth of pancreatic cancer cells.

애플리케이션

AR-A014418 has been used as an inhibitor of glycogen synthase kinase 3 (GSK3).

생화학적/생리학적 작용

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC₅₀ = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC₅₀ > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.

특징 및 장점

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves