A7007

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride

≥75%

• 동의어(들): SAM, Active methionine, AdoMet, SAM chloride dihydrochloride
• 실험식(Hill 표기법): C₁₅H₂₃ClN₆O₅S · 2 HCl
• CAS Number: 86867-01-8
• Molecular Weight: 507.82
• Beilstein: 6560002
• MDL number: MFCD22571809
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24891164
• NACRES: NA.32

속성

• Quality Level: 300
• 분석: ≥75%
• 형태: powder
• 색상: white to off-white
• solubility: H₂O: 100 mg/mL
• 응용 분야: cell analysis
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: Cl.Cl.[Cl-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;;;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);3*1H/t7-,8+,10+,11+,14+,27?;;;/m0.../s1
• InChI key: KBAFOJZCBYWKPU-XQVUROGGSA-N

설명

일반 설명

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).

애플리케이션

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.

생화학적/생리학적 작용

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

주의사항

This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.

분석 메모

Purity based on UV and HPLC.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable