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Merck
모든 사진(2)

주요 문서

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C0832

Sigma-Aldrich

Clozapine N-oxide

≥98% (HPLC), solid, 5-HT₂ serotonin receptor antagonist

동의어(들):

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C18H19ClN4O
CAS Number:
34233-69-7
Molecular Weight:
342.82
MDL number:
MFCD00210190
UNSPSC 코드:
12352119
PubChem Substance ID:
24892276
NACRES:
NA.77

product name

Clozapine N-oxide,

형태

solid

Quality Level

200

SMILES string

C[N+]1([O-])CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

OGUCZBIQSYYWEF-UHFFFAOYSA-N

일반 설명

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

애플리케이션

Clozapine N-oxide has been used:
  • for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
  • for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
  • in behavioral testing in mice and for stimulating (HEK293) cells

생화학적/생리학적 작용

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H301,H336

예방조치 성명서

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

표적 기관

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 3

1 of 3

Muscimol powder

Sigma-Aldrich

M1523

Muscimol

(±)-CPP solid

Sigma-Aldrich

C104

(±)-CPP

2,4,5-Trimethylthiazole ≥98%, FG

Sigma-Aldrich

W332518

2,4,5-Trimethylthiazole

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice
Manvich DF, et al.
Scientific Reports, 8(1), 3840-3840 (2018)
Noelle C Anastasio et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 44(10), 1752-1761 (2019-04-20)
Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli
Chemogenetic and optogenetic activation of galphas signaling in the basolateral amygdala induces acute and social anxiety-like states
Siuda ER, et al.
Neuropsychopharmacology, 41(8), 2011-2011 (2016)
Clozapine-n-oxide administration produces behavioral effects in Long-Evans rats-implications for designing DREADD experiments
MacLaren DAA, et al.
eNeuro, ENEURO-EN0219 (2016)
Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection
Li L, et al.
Current Biology, 28(6), 859-871 (2018)
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