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Merck
모든 사진(4)

주요 문서

C4695

Sigma-Aldrich

CHAPSO

BioXtra

동의어(들):

3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate

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About This Item

실험식(Hill 표기법):
C32H58N2O8S
CAS Number:
Molecular Weight:
630.88
Beilstein:
5842642
MDL number:
UNSPSC 코드:
12161900
PubChem Substance ID:
NACRES:
NA.25

설명

zwitterionic

Quality Level

제품 라인

BioXtra

분석

≥98.0% (TLC)

양식

powder

분자량

micellar avg mol wt 7000

응집 번호

11

불순물

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter (in Ethanol)

무기 잔류물

≤0.1%

CMC

8 mM (20-25°C)
8 mM (micellar weight =9960)

mp

184-186 °C (lit.)

전이 온도

cloud point 90 °C

solubility

H2O: 0.1 M at 20 °C, clear, colorless

음이온 미량물

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

양이온 미량물

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.01%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCC[N+](C)(C)CC(O)CS([O-])(=O)=O

InChI

1S/C32H58N2O8S/c1-20(7-10-29(39)33-13-6-14-34(4,5)18-23(36)19-43(40,41)42)24-8-9-25-30-26(17-28(38)32(24,25)3)31(2)12-11-22(35)15-21(31)16-27(30)37/h20-28,30,35-38H,6-19H2,1-5H3,(H-,33,39,40,41,42)/t20-,21+,22-,23?,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1

InChI key

GUQQBLRVXOUDTN-XOHPMCGNSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Chapso is a zwitterionic detergent derived from Chaps by the addition of a functional hydroxyl group. It is a nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group.

애플리케이션

Chapso has been used in a study to assess methods for high-throughput crystallization of membrane proteins. It has also been used in a study to investigate the effects of detergents on the structure of rhomboid proteases in a lipid environment.
A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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문서 라이브러리 방문

Structure of Rhomboid Protease in a Lipid Environment
Vinothkumar, K., et al.
Journal of Molecular Biology, 407, 16-16 (2011)
Incomplete Dialysis of Protein Samples Containing 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate May Lead to Erroneous Estimation of Histidine Content on Amino Acid Analysis
Nomura, K., et al.
Analytical Biochemistry, 290, 4-4 (2001)
Rachna Ujwal et al.
Journal of visualized experiments : JoVE, 9(59), e3383-e3383 (2012-01-20)
Membrane proteins (MPs) play a critical role in many physiological processes such as pumping specific molecules across the otherwise impermeable membrane bilayer that surrounds all cells and organelles. Alterations in the function of MPs result in many human diseases and
Jenny Frånberg et al.
Biochemistry, 46(25), 7647-7654 (2007-06-01)
Gamma-secretase is important for the development of Alzheimer's disease, since it is a crucial enzyme for the generation of the pathogenic amyloid beta-peptide (Abeta). Most data on gamma-secretase is derived from studies in cell lines overexpressing gamma-secretase components or amyloid
Salem Faham et al.
Protein science : a publication of the Protein Society, 14(3), 836-840 (2005-02-04)
We showed previously that high-quality crystals of bacteriorhodopsin (bR) from Halobacterium salinarum can be obtained from bicelle-forming DMPC/CHAPSO mixtures at 37 degrees C. As many membrane proteins are not sufficiently stable for crystallization at this high temperature, we tested whether

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