C6762

Cytochalasin B from Drechslera dematioidea

≥98% (HPLC), powder

• 동의어(들): Phomin
• 실험식(Hill 표기법): C₂₉H₃₇NO₅
• CAS Number: 14930-96-2
• Molecular Weight: 479.61
• Beilstein: 1096207
• EC Number: 239-000-2
• MDL number: MFCD00077704
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24892890
• NACRES: NA.32

속성

• Quality Level: 300
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white
• solubility: DMSO: 10 mg/mL
• 항생제 활성 스펙트럼: fungi
• 동작 모드: DNA synthesis | interferes
• 저장 온도: −20°C
• SMILES string: C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• InChI key: GBOGMAARMMDZGR-TYHYBEHESA-N

설명

일반 설명

Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:

• Disruption of actin filaments and of interaction of actin filaments in solution
• Inhibition of actin polymerization
• Inhibition of subunit association and dissociation

Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.

생화학적/생리학적 작용

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H361
• 예방조치 성명서: P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges