콘텐츠로 건너뛰기
Merck
모든 사진(2)

문서

C7081

Sigma-Aldrich

WY-14643

동의어(들):

4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid

로그인조직 및 계약 가격 보기
모든 사진(2)

About This Item

실험식(Hill 표기법):
C14H14ClN3O2S
CAS Number:
50892-23-4
Molecular Weight:
323.80
MDL number:
MFCD00191335
UNSPSC 코드:
12352200
PubChem Substance ID:
24892928
NACRES:
NA.77

형태

powder

SMILES string

CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2

InChI

1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

InChI key

SZRPDCCEHVWOJX-UHFFFAOYSA-N

유전자 정보

human ... PPARA(5465) , PPARD(5467) , PPARG(5468)
mouse ... Ppara(19013)
rat ... Ppara(25747)

일반 설명

WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.

애플리케이션

WY-14643 has been used:
  • as a positive control for transfection and luciferase assay
  • to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
  • to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture

생화학적/생리학적 작용

Selective PPARα agonist.

특징 및 장점

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H302,H315,H319,H335,H350

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Joe Jongpyo Lim et al.
Drug metabolism and disposition: the biological fate of chemicals, 50(10), 1396-1413 (2021-12-04)
Perfluorinated carboxylic acids (PFCAs) are widespread environmental pollutants for which human exposure has been documented. PFCAs at high doses are known to regulate xenobiotic transporters partly through peroxisome proliferator-activated receptor alpha (PPARα) and constitutive androstane receptor (CAR) in rodent models.
Vladimir S Shavva et al.
Molecular and cellular biochemistry, 448(1-2), 211-223 (2018-02-15)
Apolipoprotein A-I (ApoA-I) is the main structural and functional protein component of high-density lipoprotein. ApoA-I has been shown to regulate lipid metabolism and inflammation in macrophages. Recently, we found the moderate expression of endogenous apoA-I in human monocytes and macrophages
Stefan Clockaerts et al.
Annals of the rheumatic diseases, 71(6), 1012-1018 (2012-02-07)
Infrapatellar fat pad (IPFP) might be involved in osteoarthritis (OA) by production of cytokines. It was hypothesised that production of cytokines is sensitive to environmental conditions. To evaluate cytokine production by IPFP in response to interleukin (IL)1β and investigate the
Ronald Lucarelli et al.
Frontiers in cellular and infection microbiology, 12, 881462-881462 (2022-07-22)
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid metabolites are anti-inflammatory lipid mediators
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-alpha, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Yang R, et al.
Pharmacology, Biochemistry, and Behavior, 153, 97-104 (2017)
모든 관련된 서류 보기

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.