F6020

Fenofibrate

≥99% (TLC), powder, lipid regulating drug

• 동의어(들): 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
• 실험식(Hill 표기법): C₂₀H₂₁ClO₄
• CAS Number: 49562-28-9
• Molecular Weight: 360.83
• EC Number: 256-376-3
• MDL number: MFCD00133314
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278015
• NACRES: NA.77

속성

• 제품명: Fenofibrate, ≥99%, powder
• Quality Level: 100
• 분석: ≥99%
• 양식: powder
• 색상: off-white
• 주관자: Abbott
• 저장 온도: room temp
• SMILES string: CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2
• InChI: 1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
• InChI key: YMTINGFKWWXKFG-UHFFFAOYSA-N
• 유전자 정보: human ... PPARA(5465)

설명

애플리케이션

Fenofibrate has been used:

• to study its effect on plasma lipids, liver phenotype and gene expression
• to study its impact on endothelium-dependent vasodilatation of thoracic aorta
• to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

생화학적/생리학적 작용

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

특징 및 장점

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H373
• 예방조치 성명서: P260 - P314 - P501
• Hazard Classifications: STOT RE 2 Oral
• 표적 기관: Liver
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves