C6643

Clofibrate

liquid

• 동의어(들): 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate
• 실험식(Hill 표기법): C₁₂H₁₅ClO₃
• CAS Number: 637-07-0
• Molecular Weight: 242.70
• Beilstein: 1913459
• EC Number: 211-277-4
• MDL number: MFCD00000615
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278085
• NACRES: NA.77

속성

• 형태: liquid
• 색상: clear colorless
• density: 1.14 g/mL at 25 °C (lit.)
• 주관자: Wyeth
• 저장 온도: 2-8°C
• SMILES string: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
• InChI: 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
• InChI key: KNHUKKLJHYUCFP-UHFFFAOYSA-N
• 유전자 정보: human ... PPARA(5465) ; mouse ... Ppara(19013)

설명

애플리케이션

Clofibrate has been used:

• as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
• as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
• as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes

생화학적/생리학적 작용

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.

특징 및 장점

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H318,H335
• 예방조치 성명서: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): 235.4 °F - closed cup
• Flash Point (°C): 113 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter