D0676
Dobutamine hydrochloride
≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist
동의어(들):
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C18H23NO3 · HCl
CAS Number:
Molecular Weight:
337.84
EC Number:
MDL number:
UNSPSC 코드:
12352116
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Dobutamine hydrochloride, ≥98%
Quality Level
분석
≥98%
양식
powder
주관자
Eli Lilly
저장 온도
2-8°C
SMILES string
Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
InChI
1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChI key
BQKADKWNRWCIJL-UHFFFAOYSA-N
유전자 정보
human ... ADRB1(153) , ADRB2(154)
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애플리케이션
Dobutamine hydrochloride has been used:
- to treat mouse embryonic fibroblasts for cell death analysis
- to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
- as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging
생화학적/생리학적 작용
Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
특징 및 장점
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
개인 보호 장비
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Workbook in Practical Neonatology, 239-239 (2014)
Role of p53 in cAMP/PKA pathway mediated apoptosis
Rahimi A, et al.
Apoptosis, 18(12), 1492-1499 (2013)
Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis
Wu LMN, et al.
Cancer Cell, 33(2), 292-308 (2018)
Dobutamine (2018)
Philipp Emanuel Bartko et al.
Circulation. Cardiovascular imaging, 6(2), 268-276 (2013-01-01)
Decision making in patients with low flow-low gradient aortic stenosis mainly depends on the actual stenosis severity and left ventricular function, which is of prognostic importance. We used 2-dimensional strain parameters measured by speckle tracking at rest and during dobutamine
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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