D1069
Desloratadine
powder, ≥98% (HPLC)
동의어(들):
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®, NSC 675447
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H19ClN2
CAS Number:
Molecular Weight:
310.82
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.32
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
solubility
DMSO: >10 mg/mL
저장 온도
2-8°C
SMILES string
Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
InChI
1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI key
JAUOIFJMECXRGI-UHFFFAOYSA-N
유전자 정보
human ... HRH1(3269)
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관련 카테고리
애플리케이션
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.
생화학적/생리학적 작용
A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
법적 정보
Clarinex is a registered trademark of Schering Corp.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
390.2 °F - Pensky-Martens closed cup
Flash Point (°C)
199 °C - Pensky-Martens closed cup
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
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Villalpando-Rodriguez GE, et al.
Oxidative Medicine and Cellular Longevity, 2019 (2019)
Translational Physiology: Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome
Gasheva OY, et al.
The American Journal of Physiology, 316(1), G217-G217 (2019)
Nicholas Cutrona et al.
ACS infectious diseases, 5(8), 1397-1410 (2019-05-28)
Staphylococcus epidermidis and Staphylococcus aureus are important human pathogens responsible for two-thirds of all postsurgical infections of indwelling medical devices. Staphylococci form robust biofilms that provide a reservoir for chronic infection, and antibiotic-resistant isolates are increasingly common in both healthcare
Exposure-based validation of an in vitro gastrulation model for developmental toxicity assays
Warkus ELL and Marikawa Y
Toxicological Sciences, 157(1), 235-245 (2017)
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1294-1302 (2015-07-03)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating antihistamine used for the treatment of seasonal allergies and hives. Previously we reported that the formation of 3-hydroxydesloratadine, the major human metabolite of desloratadine, involves three sequential reactions
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