PHR1680

Desloratidine

Pharmaceutical Secondary Standard; Certified Reference Material

• 동의어(들): Desloratadine, 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex^®, NSC 675447
• 실험식(Hill 표기법): C₁₉H₁₉ClN₂
• CAS Number: 100643-71-8
• Molecular Weight: 310.82
• MDL number: MFCD00871949
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329823552
• NACRES: NA.24

속성

• Grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. Y0001584; traceable to USP 1173042
• API family: desloratidine
• CofA: current certificate can be downloaded
• 포장: pkg of 1 g
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-30°C
• SMILES string: Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
• InChI: 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChI key: JAUOIFJMECXRGI-UHFFFAOYSA-N
• 유전자 정보: human ... HRH1(3269)

설명

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Desloratadine is one of the orally active, highly selective peripheral H₁ receptor antagonists that does not exert any significant effect on the central and autonomic nervous systems. The potency of desloratadine is more than that of loratadine and it exhibits substantial overall pharmacological profile.

애플리케이션

Desloratadine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

A non-sedating H₁-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAC2775 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

법적 정보

Clarinex is a registered trademark of Schering Corp.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 390.2 °F - Pensky-Martens closed cup
• Flash Point (°C): 199 °C - Pensky-Martens closed cup