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Merck
모든 사진(4)

문서

L9664

Sigma-Aldrich

Loratadine

≥98% (HPLC), powder

동의어(들):

4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine

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모든 사진(4)

About This Item

실험식(Hill 표기법):
C22H23N2O2Cl
CAS Number:
79794-75-5
Molecular Weight:
382.88
MDL number:
MFCD00672869
UNSPSC 코드:
12352200
PubChem Substance ID:
24278525
NACRES:
NA.77

Quality Level

200

분석

≥98% (HPLC)

형태

powder

색상

white

solubility

DMSO: soluble 50 mg/mL
H2O: insoluble

주관자

Schering Plough

저장 온도

2-8°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

유전자 정보

human ... CYP3A4(1576) , HRH1(3269) , KCNH1(3756) , KCNH2(3757) , PTAFR(5724)
rat ... Hrh1(24448)

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생화학적/생리학적 작용

Loratadine is a non-sedating histamine H1-receptor antagonist. Shown to inhibit the two-pore domain potassium channel K2P18.1 (also called TRESK or KCNK18).
Non-sedating histamine H1-receptor antagonist.

특징 및 장점

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

관련 제품

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

F M Baroody et al.
Allergy, 55 Suppl 64, 17-27 (2001-04-09)
The primary mechanism of antihistamine action in the treatment of allergic diseases is believed to be competitive antagonism of histamine binding to cellular receptors (specifically, the H1-receptors), which are present on nerve endings, smooth muscles, and glandular cells. This notion
D K Strong et al.
DICP : the annals of pharmacotherapy, 25(11), 1175-1177 (1991-11-01)
Amantadine hydrochloride, a dopamine agonist with antiviral and antiparkinsonism properties, is used for the prevention and treatment of influenza A respiratory infections in high-risk populations. The occurrence of amantadine-induced hallucinations and tremors is described in a young, renal transplant patient
Mohamed El-Awady et al.
Journal of chromatography. A, 1309, 64-75 (2013-08-21)
The analysis of hydrophobic basic analytes by micellar electrokinetic chromatography (MEKC) is usually challenging because of the tendency of these analytes to be adsorbed onto the inner capillary wall in addition to the difficulty to separate these compounds as they
M Magerl et al.
The British journal of dermatology, 166(5), 1095-1099 (2012-01-17)
Cold urticaria is a rare but severe and potentially lethal condition. It is primarily treated symptomatically with H(1) -antihistamines. However, patients have a variable response to these drugs and, to date, it has not been possible to predict readily the
H Ebrahimzadeh et al.
Analytica chimica acta, 767, 155-162 (2013-03-05)
In this work a molecularly imprinted polymer was developed as a selective sorbent for extraction of loratadine (as a model) in complex matrices followed by miniaturized homogeneous liquid-liquid extraction (MHLLE) for the first time. The molecularly imprinted polymer (MIP) which
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