콘텐츠로 건너뛰기
Merck
모든 사진(3)

주요 문서

모든 문서 보기

D122

Sigma-Aldrich

Domperidone

powder, ≥98% (HPLC)

동의어(들):

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

로그인조직 및 계약 가격 보기
모든 사진(3)

About This Item

실험식(Hill 표기법):
C22H24ClN5O2
CAS Number:
57808-66-9
Molecular Weight:
425.91
EC Number:
260-968-7
MDL number:
MFCD00069256
UNSPSC 코드:
12352200
PubChem Substance ID:
24277911
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

powder

색상

white

solubility

DMSO: >10 mg/mL
0.1 M HCl: soluble
0.1 M NaOH: slightly soluble
H2O: insoluble

주관자

Johnson & Johnson

SMILES string

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

유전자 정보

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , KCNH2(3757)
rat ... Drd1a(24316) , Drd2(24318) , Drd3(29238) , Htr3a(79246)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

특징 및 장점

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Health hazard
GHS08

신호어

Warning

유해 및 위험 성명서

H361fd

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.
P M Laduron et al.
Biochemical pharmacology, 28(14), 2161-2165 (1979-07-15)
Luc M Hondeghem
Journal of cardiovascular pharmacology, 61(3), 218-225 (2012-11-29)
Domperidone (antinausea/vomiting agent) was recently shown by several groups to increase sudden cardiac death (SCD). Drug-induced disturbances of cardiac repolarization may be a major mechanism. Experiments were executed in isolated female rabbit hearts perfused for 150 minutes with domperidone 30
D S Pritchard et al.
British journal of clinical pharmacology, 59(6), 725-729 (2005-06-14)
To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children. Systematic review of randomized controlled trials (RCTs). A search was made of the Cochrane
M C Champion et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 135(5), 457-461 (1986-09-01)
Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract
Elizabeth V Asztalos et al.
BMC pregnancy and childbirth, 12, 87-87 (2012-09-01)
The use of mother's own breast milk during initial hospitalization has a positive impact not only in reducing potential serious neonatal morbidities but also contribute to improvements in neurodevelopmental outcomes. Mothers of very preterm infants struggle to maintain a supply
모든 관련된 서류 보기

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.