D6140

Demeclocycline hydrochloride

powder or crystals, suitable for cell culture

• 동의어(들): 7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride
• 실험식(Hill 표기법): C₂₁H₂₁ClN₂O₈ · HCl
• CAS Number: 64-73-3
• Molecular Weight: 501.31
• Beilstein: 3849198
• EC Number: 200-592-2
• MDL number: MFCD00082371
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24278380
• NACRES: NA.75

속성

• 제품명: Demeclocycline hydrochloride, powder or crystals
• 분석: 89.5-102.0% anhydrous basis
• Quality Level: 200
• 양식: powder or crystals
• 기술: cell culture | mammalian: suitable
• solubility: soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• 저장 온도: −20°C
• SMILES string: Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
• InChI: 1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
• InChI key: GVSJQNRGSCOSNJ-KBHRXELFSA-N

설명

일반 설명

Chemical structure: tetracycline

생화학적/생리학적 작용

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.

Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302 + H312 + H332,H315,H319,H335,H341
• 예방조치 성명서: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves