E7131

[D-Ala², D-Leu⁵]-Enkephalin acetate salt

≥95% (HPLC)

• 동의어(들): DADLE
• 실험식(Hill 표기법): C₂₉H₃₉N₅O₇
• CAS Number: 94825-57-7
• Molecular Weight: 569.65
• MDL number: MFCD00133947
• UNSPSC 코드: 12352209
• PubChem Substance ID: 329799004
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥95% (HPLC)
• 저장 온도: −20°C
• SMILES string: CC(O)=O.CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
• InChI: 1S/C29H39N5O7.C2H4O2/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20;1-2(3)4/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41);1H3,(H,3,4)/t18-,22+,23+,24-;/m1./s1
• InChI key: YRZBXSPTRALQEX-IIKZURRYSA-N
• 유전자 정보: human ... OPRD1(4985) ; mouse ... OPRD1(18386) ; rat ... OPRD1(24613)

설명

Amino Acid Sequence

Tyr-Ala-Gly-Phe-Leu

일반 설명

[D-Ala², D-Leu⁵]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.

애플리케이션

[D-Ala², D-Leu⁵]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70^s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.

생화학적/생리학적 작용

Prototypical δ-agonist; more potent and selective than Leu-enkephalin and Met-enkephalin.

[D-Ala², D-Leu⁵]-Enkephalin can induce hibernation in ground squirrels, during summers, when they do not normally hibernate. In multiorgan block preparation, it can prolong the survival time of organs such as, heart, lung, liver, spleen and kidney, up to 46hrs. It aids in tolerance development of myocardium to ischemia. It might have tissue protective role in central nervous system. It prevents and reverses methamphetamine (METH)-induced damage of dopaminergic terminals of brain. It prevents naltrexone-sensitive PC12 cell apoptosis in serum deprivation conditions. Thus, it might play an essential role in the survival of neurons and organs.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)