E7881

Emodin

from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor

• 동의어(들): 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione, 1,3,8-Tri­hydroxy-6-methyl­anthra­quinone, 6-Methyl-1,3,8-tri­hydroxy­anthra­quinone, Archin, Emodol, Frangula-emodin, Frangulic acid, Rheum emodin
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 518-82-1
• Molecular Weight: 270.24
• Beilstein: 1888141
• EC Number: 208-258-8
• MDL number: MFCD00001207
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278164
• NACRES: NA.77

속성

• product name: Emodin, from Frangula bark, ≥90% (HPLC)
• 생물학적 소스: Frangula bark
• 분석: ≥90% (HPLC)
• solubility: DMSO: soluble; aqueous base: soluble; ethanol: soluble
• 저장 온도: 2-8°C
• SMILES string: Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• InChI key: RHMXXJGYXNZAPX-UHFFFAOYSA-N
• 유전자 정보: human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)

설명

일반 설명

Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.

애플리케이션

Emodin has been used:

• to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
• as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
• to inhibit Tau aggregation
• for direct binding assay

생화학적/생리학적 작용

Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves