추천 제품
분석
≥98% (HPLC)
양식
solid
색상
white
solubility
DMSO: ≥20 mg/mL
H2O: insoluble
ethanol: soluble
주관자
Johnson & Johnson
저장 온도
room temp
SMILES string
Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
InChI
1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
InChI key
QOYHHIBFXOOADH-UHFFFAOYSA-N
유전자 정보
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).
Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.
생화학적/생리학적 작용
Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.
Fluspirilene is a dopamine receptor antagonist. It also acts as a calcium channel blocker. Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties. It exhibits therapeutic effects against glioblastoma and Schizophrenia.
특징 및 장점
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Christine Zalejski et al.
Plant physiology, 141(4), 1555-1562 (2006-06-13)
Diacylglycerol pyrophosphate (DGPP) was recently shown to be a possible intermediate in abscisic acid (ABA) signaling. In this study, reverse transcription-PCR of ABA up-regulated genes was used to evaluate the ability of DGPP to trigger gene expression in Arabidopsis (Arabidopsis
Su-Jane Wang
Synapse (New York, N.Y.), 44(1), 36-41 (2002-02-14)
Fluspirilene, a neuroleptic drug which is used clinically to treat schizophrenic patients, is a dopamine D2 receptor antagonist. Besides its well-known actions on the dopamine receptors, fluspirilene also displays calcium channel-blocking activity. The aim of this study was to investigate
Qin Cao et al.
Nature chemistry (2018-10-10)
Inhibiting the interaction between amyloid-β (Aβ) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer's disease. Supporting this approach, Alzheimer's-like symptoms are reduced in mouse models following genetic depletion of the LilrB2
Fluspirilene block of N-type calcium current in NGF-differentiated PC 12 cells
Grantham, CJ and Main, MJ and Cannell, MB
British Journal of Pharmacology, 111(2), 483-488 (1994)
Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists.
Sah, DW and Bean, Bruce P
Molecular Pharmacology, 45(1), 84-92 (1994)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.