F9505

Furazolidone

• 동의어(들): 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone
• 실험식(Hill 표기법): C₈H₇N₃O₅
• CAS Number: 67-45-8
• Molecular Weight: 225.16
• Beilstein: 8317414
• EC Number: 200-653-3
• MDL number: MFCD00010550
• UNSPSC 코드: 51102829
• PubChem Substance ID: 24894997
• NACRES: NA.85

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 양식: powder
• 색상: yellow
• mp: 256-256 °C
• solubility: formic acid: 50 mg/mL
• 항생제 활성 스펙트럼: Gram-positive bacteria; parasites
• 동작 모드: enzyme | inhibits
• SMILES string: [O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1
• InChI: 1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
• InChI key: PLHJDBGFXBMTGZ-WEVVVXLNSA-N

설명

애플리케이션

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca²⁺-ATPase in chick cardiac myocytes.

생화학적/생리학적 작용

Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361fd
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges