G0549
Corosolic acid from Lagerstroemia speciosa
≥98% (HPLC)
동의어(들):
Corosolic acid, (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid, 2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol
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모든 사진(3)
About This Item
실험식(Hill 표기법):
C30H48O4
CAS Number:
Molecular Weight:
472.70
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.25
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
solubility
methanol: 1 mg/mL, clear, colorless
응용 분야
metabolomics
vitamins, nutraceuticals, and natural products
저장 온도
2-8°C
SMILES string
O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1
InChI
1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
InChI key
HFGSQOYIOKBQOW-ZSDYHTTISA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Corosolic acid from Lagerstroemia speciosa is a pentacyclic triterpenoid found in a variety of plants, such as apples, basil, bilberries, cranberries, and prunes. It is a natural derivative of ursolic acid.
애플리케이션
Corosolic acid from Lagerstroemia speciosa has been used to study the inhibiting activity of ursolic acid and its derivative against colon cancer cells by causing degradation of β-catenins.
생화학적/생리학적 작용
Corosolic acid from Lagerstroemia speciose shows a variety of biological activities such as anti-proliferation, apoptosis, and anti-carcinogenic. It exhibits an inhibiting effect on the post-challenge plasma glucose levels in humans. Corosolic acid, due to its ability to improve glucose metabolism, has been touted to be used in the management of Type-2 Diabetes. It improves hypertension, oxidative stress, and inflammation, thereby being a potential candidate to be used against atherosclerosis-related diseases.
Triterpene phytochemical found in medicinal herbal extracts. Possesses antiatherosclerotic, antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral and antineoplastic activities.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Joo-Hyun Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 67, 87-95 (2014-02-26)
Ursolic acid (UA) and corosolic acid (CA), naturally occurring pentacyclic triterpene acids, exhibit antiproliferative activities against various cancer cells, but a clear chemopreventive mechanism of these triterpenoids in colon cancer cells remains to be answered. Here we used a cell-based
Yu Yamaguchi et al.
Life sciences, 79(26), 2474-2479 (2006-09-09)
Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities. The aim of this study was to determine the effects of CRA on metabolic risk factors including obesity, hypertension, hyperinsulinemia, hyperglycemia, and hyperlipidemia
Yanfeng Xu et al.
Cancer letters, 284(2), 229-237 (2009-05-22)
We investigated the response of human cervix adenocarcinoma HeLa cells to Corosolic acid (CRA) treatment. Our results showed that CRA significantly inhibited cell viability in both a dose- and a time-dependent manner. CRA treatment induced S cell-cycle arrest and caused
Toshihiro Miura et al.
Biological & pharmaceutical bulletin, 29(3), 585-587 (2006-03-02)
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA
M Fukushima et al.
Diabetes research and clinical practice, 73(2), 174-177 (2006-03-22)
Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on
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