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Merck
모든 사진(1)

주요 문서

G7637

Sigma-Aldrich

Guanosine 5′-[β-thio]diphosphate trilithium salt

≥85% (HPLC), powder

동의어(들):

GDPβS trilithium salt, GDP-β-S, GDP-β-S-Li3

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About This Item

실험식(Hill 표기법):
C10H12Li3N5O10P2S
CAS Number:
Molecular Weight:
477.07
Beilstein:
8181243
MDL number:
UNSPSC 코드:
41106305
PubChem Substance ID:
NACRES:
NA.77

Quality Level

분석

≥85% (HPLC)

형태

powder

색상

white

solubility

H2O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

LMCWQGPJYZRMKU-CYCLDIHTSA-K

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Guanosine 5′-[β-thio]diphosphate trilithium salt has been used as an inhibitor of G-protein activation to study its effects on acetylcholine current in bag cell neurons. It has also been used to study its effects on cholinergic-dependent plateau potentials.

생화학적/생리학적 작용

Guanosine 5′-[β-thio]diphosphate is a non-hydrolyzable analog of guanosine. It functions as an inhibitor of G-protein activation.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

결합

Non-hydrolyzable GDP analog

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

E Oberdisse et al.
Biochemical and biophysical research communications, 144(3), 1188-1196 (1987-05-14)
Guanosine 5'-O-thiotriphosphate (GTP gamma S) and thrombin stimulate the activity of phospholipase C in platelets that have been permeabilized with saponin and whose inositol phospholipids have been prelabeled with [3H]inositol. Ca2+ has opposite effects on the formation of [3H]inositol phosphates
E Y Moon et al.
Life sciences, 86(17-18), 683-690 (2010-03-03)
We evaluated Gi-protein inhibitor, guanosine 5'-O-(2-thiodiphosphate)(GOT)-induced senescence-associated(SA)-beta-galactosidase(Gal) positive cell formation to determine if it occurred through phosphorylation of cyclic AMP-dependent response element binding protein (CREB). IMR-90 human lung fibroblast cells were used. SA-beta-Gal positive cells and senescence-associated heterochromatic foci (SAHF)
R J Ho et al.
Archives of biochemistry and biophysics, 251(1), 148-155 (1986-11-15)
Forskolin-activated adenylate cyclases (AC) in intact membranes, solubilized with Lubrol or eluted following adsorption on a forskolin-Sepharose column, were examined for inhibition by GDP and GDP beta S. AC in intact membranes of rat or rabbit adipocytes was activated by
A K H Tam et al.
Neuroscience, 179, 41-55 (2011-02-01)
Targeting signalling molecules to ion channels can expedite regulation and assure the proper transition of changes to excitability. In the bag cell neurons of Aplysia, single-channel studies of excised patches have revealed that protein kinase C (PKC) gates a non-selective
G L Kucera et al.
Biochemical and biophysical research communications, 153(1), 417-421 (1988-05-31)
The inhibition by guanosine 5'-[beta-thio]diphosphate (GDP beta S) of phospholipase C was compared in intact and saponin-permeabilized human platelets in order to assess whether effects of GDP beta S on phospholipase C activation unrelated to guanine nucleotide binding function were

문서

고리형 AMP(cAMP), 고리형 GMP(cGMP), 고리형 ADP-리보스를 포함하여 고리형 뉴클레오타이드는 GPCR 활성화에 의해 개시된 세포내 이벤트의 2차 전달자로서 광범위하게 연구되었습니다. cAMP는 주로 cAMP 의존성 단백질 인산화효소(PKA)의 활성화를 통해 모든 진핵생물 세포에서 세포 기능을 변형시키지만 cAMP 개폐 이온 채널 및 cAMP에 의해 직접 활성화되는 구아닌 뉴클레오타이드 교환 인자를 통해서도 변형시킵니다.

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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