G8764

Gc-globulin from human plasma

≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)

• 동의어(들): DBP, Group-Specific Component, Vitamin D Binding Protein
• CAS Number: 68476-36-8
• MDL number: MFCD00131143
• UNSPSC 코드: 12352202
• NACRES: NA.61

속성

• 생물학적 소스: human plasma
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 양식: lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
• 분자량: ~52 kDa
• 기술: LC/MS: suitable
• solubility: H₂O: soluble 2 mg/mL
• UniProt 수납 번호: P02774
• 저장 온도: −20°C
• 유전자 정보: human ... GC(2638)

설명

일반 설명

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.

Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.

Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.

애플리케이션

Gc-globulin from human plasma has been used:

• as a fluorescent probe for G-actin staining
• as a fluorescent probe to monitor steady-state rate of actin filament disassembly
• as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)

Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.

생화학적/생리학적 작용

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.

Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].

제조 메모

Native Gc-globulin from human plasma

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable