H0786

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• 동의어(들): HRG-β
• MDL number: MFCD01867052
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥80% (SDS-PAGE)
• 형태: buffered aqueous glycerol solution
• 분자량: 185 kDa
• 포장: pkg of 100 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• UniProt 수납 번호: Q02297
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... NRG1(3084)

설명

일반 설명

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

생화학적/생리학적 작용

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

물리적 형태

Solution in phosphate buffered saline containing 30% glycerol.

분석 메모

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable