추천 제품
생물학적 소스
bovine muscle
Quality Level
유형
Type X
분석
3.0—25.0 mg protein/mL (biuret)
양식
ammonium sulfate suspension
특이 활성도
≥600 units/mg protein
제조업체/상표
Sigma-Aldrich
기술
activity assay: suitable
색상
white
pH
7.5
응용 분야
life science and biopharma
외래 활성
pyruvate kinase ≤0.01%
저장 온도
2-8°C
유전자 정보
cow ... LDHA(281274) , LDHB(281275)
일반 설명
Research Area: Cell Signaling
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
애플리케이션
L-Lactic Dehydrogenase from bovine muscle has been used in lactate assay to assess lactate tissue accumulation.
생화학적/생리학적 작용
Lactate dehydrogenase (LDH) plays a critical role as a checkpoint in gluconeogenesis and DNA metabolism. It plays a vital role in maintaining homeostasis during periods of low oxygen availability. As an oxidoreductase enzyme, lactate dehydrogenase catalyzes the reversible conversion of pyruvate to lactate using NADH. This enzyme is crucial for the anaerobic metabolism of glucose when oxygen is either absent or in short supply. LDH is the sole serum biomarker effective for evaluating metastatic melanomas.
Also catalyzes the oxidation of other L-2-hydroxymonocarboxylic acids.
단위 정의
One unit will reduce 1.0 μmole of pyruvate to L-lactate per min at pH 7.5 at 37 °C.
물리적 형태
Crystalline suspension in 2.4 M (NH4)2SO4 solution, pH 6.0
분석 메모
Protein determined by biuret.
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
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문서
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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