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Merck
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주요 문서

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N9162

Sigma-Aldrich

Neocarzinostatin

from Streptomyces carzinostaticus, ≥90% (SDS-PAGE), solution

동의어(들):

Holoneocarzinostatin, NCS, NSC-69856, Zinostatin

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모든 사진(3)

About This Item

CAS Number:
9014-02-2
MDL number:
MFCD01778130
UNSPSC 코드:
12352200
NACRES:
NA.77

product name

Neocarzinostatin from Streptomyces carzinostaticus, ≥90% (SDS-PAGE), ~0.5 mg/mL

Quality Level

200

분석

≥90% (SDS-PAGE)

형태

solution

농도

~0.5 mg/mL

항생제 활성 스펙트럼

neoplastics

동작 모드

DNA synthesis | interferes

배송 상태

wet ice

저장 온도

2-8°C

InChI

1S/C35H35NO12/c1-16-12-19(42-4)14-22-20(16)8-9-23(37)27(22)32(40)45-24-13-18-10-11-35(26-15-43-34(41)46-26)25(48-35)7-5-6-21(18)31(24)47-33-28(36-3)30(39)29(38)17(2)44-33/h8-9,12-14,17,21,24-26,28-31,33,36-39H,6,15H2,1-4H3/t17-,21?,24-,25-,26-,28-,29+,30-,31-,33-,35+/m1/s1

InChI key

BLXZMHNVKCEIJX-PNKAXBHOSA-N

애플리케이션

Neocarzinostatin from Streptomyces carzinostaticus has been used:
  • as a DNA damaging agent to treat human fibroblast GM0637 cells
  • as a radiomimetic antibiotic to induce DNA damage
  • in combination with Vγ2Vδ2 T cells to determine the cytotoxicity in ovarian cancer cells

생화학적/생리학적 작용

Neocarzinostatin is a protein-small molecule complex composed of an enediyne chromophore tightly bound to a 113 amino acid single chain protein. The complex possesses antiproliferative and antitumor activity. The chromophore is the active compound, which is responsible for DNA cleavage; while the apoprotein stabilizes and regulates the availability of the labile chromophore. NCS chromophore is bound non-covalently in a cleft of the binding protein and is dissociable. Upon addition of a thiol, the chromophore forms a highly reactive biradical species that can induce sequence-specific single and double strand breaks in DNA. Neocarzinostatin inhibits DNA synthesis and possesses antitumor activity in various human and animal tumors. NCS inhibits cellular proliferation by inducing G2 cell cycle arrest and apoptosis in both human papillomavirus (HPV) positive and negative cell lines.
Neocarzinostatin is a radiomimetic antibiotic substance.

물리적 형태

Supplied as 100 μg (~9 nmoles) in a solution containing 20 mM MES buffer, pH 5.5.

Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway
Wan G, et al.
Cellular Signalling, 25(5), 1086-1095 (2013)
Induction of ATM/ATR pathway combined with Vgamma2Vdelta2 T cells enhances cytotoxicity of ovarian cancer cells
Lu J,et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1842(7), 1071-1079 (2014)
B Heyd et al.
Journal of bacteriology, 182(7), 1812-1818 (2000-03-14)
Neocarzinostatin (NCS) is the most studied member of a family of chromoproteins secreted by a range of actinomycetes species. It has been proposed that in addition to their antitumoral activity related to the bound chromophores, this group of related proteins
Neocarzinostatin-chromophore: a potent inhibitor of casein kinase II in vitro.
Tanoue, S., et al.
Antibiotics, 51, 95-98 (1998)
The enediyne antibiotics.
A L Smith et al.
Journal of medicinal chemistry, 39(11), 2103-2117 (1996-05-24)
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