O4636

Oxytetracycline dihydrate

Assay (anhydrous basis) 95.0%-102.0%

• 동의어(들): 5-Hydroxytetracycline dihydrate, Oxytetracycline, Oxytetracycline Anhydrous
• 실험식(Hill 표기법): C₂₂H₂₄N₂O₉ · 2H₂O
• CAS Number: 6153-64-6
• Molecular Weight: 496.46
• EC Number: 201-212-8
• MDL number: MFCD00151234
• UNSPSC 코드: 51284038
• PubChem Substance ID: 24898000
• NACRES: NA.85

속성

• Quality Level: 200
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• SMILES string: O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• InChI: 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1
• InChI key: IBZHEBHGZFICKS-IFLJXUKPSA-N

설명

일반 설명

Chemical structure: tetracycline

애플리케이션

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.

생화학적/생리학적 작용

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

분석 메모

solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions

기타 정보

10g,50g

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS08,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H361d,H411
• 예방조치 성명서: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)