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Merck
모든 사진(3)

주요 문서

P2443

Sigma-Aldrich

Pluronic® F-127

powder, BioReagent, suitable for cell culture

동의어(들):

Non-ionic copolymer surfactant

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About This Item

Linear Formula:
(C3H6O·C2H4O)x
CAS Number:
MDL number:
UNSPSC 코드:
12161902
PubChem Substance ID:
NACRES:
NA.75

설명

Non-ionic
contains 100ppm BHT

Quality Level

제품 라인

BioReagent

양식

powder

분자량

~12600 g/mol

기술

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

전이 온도

cloud point >100 °C

HLB

18 - 23

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

일반 설명

Pluronicpluronic® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.

애플리케이션

Pluronic® F-127 has been used:

  • as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
  • as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
  • in the preparation of calcium indicator stock solution for measuring neural activities.
  • as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
  • This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.

생화학적/생리학적 작용

Pluronic® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.

법적 정보

Pluronic is a registered trademark of BASF

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Federico Ceriani et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7194-E7201 (2016-11-04)
Spatially and temporally coordinated variations of the cytosolic free calcium concentration ([Ca2+]c) play a crucial role in a variety of tissues. In the developing sensory epithelium of the mammalian cochlea, elevation of extracellular adenosine trisphosphate concentration ([ATP]e) triggers [Ca2+]c oscillations
Philippe Marmottant et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17271-17275 (2009-10-07)
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If
Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding
Ghatnekar GS, et al.
Regenerative Medicine, 4(2), 205-223 (2009)
Environmentally responsive injectable materials
Bearat HH and Vernon BL
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 263-297 (2011)
PLURONIC F127 and ITS applications
Salama AH
Pharmacology, 2, 1393- 1403 (2021)

문서

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

관련 콘텐츠

조직 공학은 손상된 조직을 치료하거나 대체하기 위해 인체의 미세 환경을 시뮬레이션함으로써 지지체, 생세포, 생물학적 활성 분자로부터 조직을 배양합니다.

Tissue engineering fabricates tissues cultures from scaffolds, living cells, and biologically active molecules by simulating the microenvironment of the body to repair or replace damaged tissue.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.