S8442

SU 5416

≥98% (HPLC), powder, neuronal nitric oxide synthase inhibitor

• 동의어(들): 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
• 실험식(Hill 표기법): C₁₅H₁₄N₂O
• CAS Number: 204005-46-9
• Molecular Weight: 238.28
• MDL number: MFCD01940922
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278606
• NACRES: NA.77

속성

• product name: SU 5416, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: yellow to yellow-orange
• mp: 221-222 °C
• solubility: DMSO: 20 mg/mL, clear (warmed); H₂O: insoluble
• 저장 온도: −20°C
• SMILES string: Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
• InChI: 1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
• InChI key: WUWDLXZGHZSWQZ-XYOKQWHBSA-N
• 유전자 정보: human ... EGFR(1956) , FLT1(2321) , IGFBP1(3484) , IL2(3558) , KDR(3791) , PDGFRB(5159) ; mouse ... Flt1(14254) , Kdr(16542)

설명

일반 설명

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. SU 5416 is known to prevent tumor growth and tumor angiogenesis. SU 5416 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity. It also acts as an agonist of aryl hydrocarbon receptor and may be an effective clinical agent for treating autoimmune diseases and transplant rejection.

애플리케이션

SU 5416 has been used to treat HUVEC cells before the tube formation assay to assess its impact on the network generated from tube formation. to induce pulmonary hypertension (PH) in mice to serve as an experimental model

생화학적/생리학적 작용

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.¹ It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.²

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves