SAB4502981

Anti-Claudin 5, C-Terminal antibody produced in rabbit

affinity isolated antibody

• 동의어(들): CLD5, CLDN5, TMDVCF, Transmembrane protein deleted in VCFS
• MDL number: MFCD03454913
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 23 kDa
• 종 반응성: mouse, human, rat
• 농도: ~1 mg/mL
• 기술: ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: O00501
• UniProt 수납 번호: O00501
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CLDN5(7122)

설명

일반 설명

Anti-Claudin 5 Antibody detects endogenous levels of total Claudin 5 protein.

The CLDN5 (claudins) gene is mapped to human chromosome 22q11.21 and codes for a transmembrane protein, which is a component of tight junction. The protein is a part of blood-brain barrier. The encoded protein is 303 - 218 amino acids long.

면역원

The antiserum was produced against synthesized peptide derived from human Claudin 5.

Immunogen Range: 169-218

애플리케이션

Anti-Claudin 5, C-Terminal antibody produced in rabbit has been used for intravascular perfusion labelling of vascular endothelial- cadherin and Immunofluorescence.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

생화학적/생리학적 작용

The CLDN5 (claudins) gene encodes a component of tight junction and serves as a selective barrier for solutes and water. Upregulation of CLDN5 was observed in migraine. The expression of CLDN5 is reduced in lung squamous carcinoma. CLDN5 is known to increase p21 and decrease cyclin D1, leading to the retardation of cell cycle G1 to S transition. Cldn5 maintains homeostasis of the central nervous system, being a part of blood-brain barrier.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable