모든 사진(1)

주요 문서

COO/COA

모든 문서 보기

SML0741

ML324

Name: ML324
Brand: SIGMA

≥98% (HPLC)

동의어(들):

N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

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모든 사진(1)

About This Item

실험식(Hill 표기법):

C₂₁H₂₃N₃O₂

CAS Number:

1222800-79-4

Molecular Weight:

349.43

MDL number:

MFCD28053518

UNSPSC 코드:

12352200

PubChem Substance ID:

329825592

NACRES:

NA.77

추천 제품

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Sigma-Aldrich

K4394

PKF118-310

Sigma-Aldrich

T2879

Tyramine hydrochloride

Sigma-Aldrich

L8000

L-Leucine

Sigma-Aldrich

N5751

N_ω-Nitro-L-arginine methyl ester hydrochloride

Sigma-Aldrich

SML0343

Methylstat

Supelco

PHR1084

Metformin hydrochloride

Sigma-Aldrich

M9625

L-Methionine

Sigma-Aldrich

A6476

ABT-418 hydrochloride

Sigma-Aldrich

P2126

L-Phenylalanine

Sigma-Aldrich

PZ0262

PF-06663195

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated

색상

white to light brown

solubility

DMSO: 10 mg/mL, clear

저장 온도

2-8°C

SMILES string

CN(C)CCCNC(C1=CC=C(C2=CC(O)=C(N=CC=C3)C3=C2)C=C1)=O

InChI

1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

InChI key

QDBVSOZTVKXUES-UHFFFAOYSA-N

생화학적/생리학적 작용

ML324 is a potent JMJD2 demethylase inhibitor that is highly effective in reducing herpes simplex virus (HSV) IE gene expression. ML324 potently blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.

ML324 is a potent JMJD2 demethylase inhibitor.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

David M Carter et al.

SLAS discovery : advancing life sciences R & D, 22(7), 801-812 (2017-03-28)

Human lysine demethylase (KDM) enzymes (KDM1-7) constitute an emerging class of therapeutic targets, with activities that support growth and development of metastatic disease. By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate

JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.

Lei Duan et al.

Oncogene, 38(28), 5643-5657 (2019-04-11)

Platinum-based drugs such as cisplatin (CP) are the first-line chemotherapy for non-small-cell lung carcinoma (NSCLC). Unfortunately, NSCLC has a low response rate to CP and acquired resistance always occurs. Histone methylation regulates chromatin structure and is implicated in DNA repair.

Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.

Robert Kleszcz et al.

Cellular oncology (Dordrecht), 42(4), 505-520 (2019-05-16)

Activation of the Wnt pathway contributes to the development of head and neck squamous cell carcinomas (HNSCC) and its inhibition has recently emerged as a promising therapeutic strategy. Here, we aimed at identifying suitable molecular targets for down-regulation of canonical

Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression.

Salil Saurav Pathak et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(4), 854-863 (2016-10-27)

Major depressive disorder (MDD) is debilitating mental illness and is one of the leading contributors to global burden of disease, but unfortunately newer and better drugs are not forthcoming. The reason is lack of complete understanding of molecular mechanisms underlying

KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels.

Ji-Young Choi et al.

Scientific reports, 7, 45005-45005 (2017-03-23)

Intercellular adhesion molecule 1 (ICAM1) mediates the adhesion and transmigration of leukocytes across the endothelium, promoting inflammation. We investigated the epigenetic mechanism regulating ICAM1 expression. The pro-inflammatory cytokine TNF-α dramatically increased ICAM1 mRNA and protein levels in human brain microvascular

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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

주요 문서

ML324

≥98% (HPLC)

About This Item

추천 제품

속성

Quality Level

분석

양식

저장 조건

색상

solubility

저장 온도

SMILES string

InChI

InChI key

설명

생화학적/생리학적 작용

특징 및 장점

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

문서

시험 성적서(COA)

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