SRP4011

Cardiotrophin-1 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 동의어(들): CT1, CTF1, Cardiophin 1
• MDL number: MFCD01865988
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 형태: lyophilized
• 분자량: ~22.5 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 불순물: endotoxin, tested
• NCBI 수납 번호: Q16619
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... CTF1(1489)

설명

일반 설명

Cardiotrophin-1 belongs to the interleukin-6 (IL-6) family of cytokines. It is a cytoprotective protein. The gene is mapped to human chromosome 16p11.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.

생화학적/생리학적 작용

Cardiotrophin-1 signals via β receptor glycoprotein 130 (gp130) and β receptor leukemia inhibitory factor receptor (LIFR). It confers protective role on cardiac myocytes. Cardiotrophin-1 protects cardiomyocytes from cell death, however, it can also induce cardiac hypertrophy. It is also involved in neural tissue development and helps in protection of the mature nervous system from injuries and dysfunction. Cardiotrophin-1 also protects liver against injury. It is also involved in the control of body weight and intermediate metabolism. In mouse model, it protects β cells from apoptosis. It also promotes glucose-mediated insulin secretion. Absence of the cardiotrophin-1 gene in mice is associated with obesity, hyperglycemia, hyperinsulinemia and hypercholesterolemia.

물리적 형태

Sterile filtered and then lyophilized in 1 x PBS.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in 20 mM Tris, pH 8.0 to a concentration of <1.0 mg/mL. The solution can be diluted into other aqueous buffers.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable