추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥90% (SDS-PAGE)
형태
liquid
분자량
23.5 kDa (115-329 aa)
포장
pkg of 5 μg
pkg of 50 μg
농도
0.5 mg/mL
기술
activity assay: suitable
적합성
suitable for molecular biology
UniProt 수납 번호
응용 분야
life science and biopharma
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... CTSK(1513)
일반 설명
Cathepsin K is expressed as procathepsin K, which is the inactive proenzyme of cathepsin K. Cathepsin K is a lysosomal cysteine protease and part of the papain cysteine protease family. It is expressed in osteoclasts. The gene encoding this protein is localized on human chromosome 1q21.
생화학적/생리학적 작용
Cathepsin K has a role in bone resorption and remodeling. It has a triple helical collagen hydrolase activity. Mutations in the gene encoding this protein have been linked to pycnodysostosis.
물리적 형태
0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease.
Bobillo L J, et al.
Medicina clinica, 145(7), 281-287 (2015)
Diana J Leeming et al.
BMC cancer, 8, 180-180 (2008-07-01)
Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of the present study was to determine whether
Familial pycnodysostosis: identification of a novel mutation in the CTSK gene (cathepsin K).
Toral-Lopez J, et al.
Journal of Investigative Medicine, 59(2), 277-280 (2011)
Autocatalytic activation of human cathepsin K.
McQueney M S, et al.
The Journal of Biological Chemistry, 272(21), 13955-13960 (1997)
A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin.
Huang X, et al.
Calcified Tissue International, 96(5), 373-378 (2015)
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