V3639

Valinomycin

Ready Made Solution, ~1 mg/mL in DMSO

• 동의어(들): Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
• 실험식(Hill 표기법): C₅₄H₉₀N₆O₁₈
• CAS Number: 2001-95-8
• Molecular Weight: 1111.32
• Beilstein: 78657
• MDL number: MFCD00005114
• UNSPSC 코드: 51102829
• PubChem Substance ID: 24900743
• NACRES: NA.76

속성

• 생물학적 소스: Streptomyces sp.
• Quality Level: 200
• 분석: ≥90% (HPLC)
• 형태: liquid
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
• 농도: ~1 mg/mL in DMSO
• 색상: colorless
• 항생제 활성 스펙트럼: Gram-positive bacteria; parasites; viruses
• 동작 모드: cell membrane | interferes
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• SMILES string: CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• InChI key: FCFNRCROJUBPLU-RPUZOQEISA-N

설명

일반 설명

Chemical structure: peptide

애플리케이션

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

생화학적/생리학적 작용

K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F - closed cup
• Flash Point (°C): 87 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter