SML1779

Nigericin sodium salt

from Streptomyces hygroscopicus, ≥98% (HPLC), solution, polyether ionophore

• 동의어(들): 3B2-6379, Antibiotic K178, Antibiotic X464, Azalomycin M, HE331800, Helexin C, Polyetherin A, sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
• 실험식(Hill 표기법): C₄₀H₆₇NaO₁₁
• CAS Number: 28643-80-3
• Molecular Weight: 746.94
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: Nigericin sodium salt Ready Made Solution, 5 mg/mL (DMSO:ethanol 1:1)
• 생물학적 소스: Streptomyces hygroscopicus
• Quality Level: 200
• 형태: solution
• 농도: 5 mg/mL (DMSO:ethanol 1:1)
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: cell membrane | interferes
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
• InChI key: MOYOTUKECQMGHE-KKCUGXASSA-M

설명

생화학적/생리학적 작용

Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K⁺) for H⁺ (antiport). Nigericin transports monovalent cations across membranes with the following specificity: K⁺ >Rb⁺ >Cs⁺ >>Na⁺ and thus, disrupts membrane potential and stimulates ATPase activity in mitochondria.
Nigericin kills bacteria by facilitating the diffusion of ions across membranes.
Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus. Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems.

제조 메모

Nigericin sodium salt ready made solution is provided at 6.7 mM concentration. The solution can be further diluted with a desired solvent to a working concentration (0.5-10 μM).

This product is a 5 mg/mL solution prepared in a 1:1 mixture of DMSO and Ethanol.

저장 및 안정성

The product can be stored at 2-8°C and is released with a 4 years suggested retest schedule. The solution is quite stable refrigerated and freezing is not necessary.

안전성 정보

• 픽토그램: GHS02
• 신호어: Warning
• 유해 및 위험 성명서: H226
• 예방조치 성명서: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 3
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 78.8 °F
• Flash Point (°C): 26 °C