1396309

Metformin hydrochloride

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): 1,1-Dimethylbiguanide hydrochloride, Metformin
• Linear Formula: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• CAS Number: 1115-70-4
• Molecular Weight: 165.62
• MDL number: MFCD00012582
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329750380
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: metformin
• 제조업체/상표: USP
• mp: 223-226 °C (lit.)
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• SMILES string: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• InChI key: OETHQSJEHLVLGH-UHFFFAOYSA-N

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Metformin hydrochloride USP reference standard for specified tests and assay use.

Also used to prepare standard, mixed standard stock and system suitability solutions for the assay, impurity analysis and performance tests according to the given below monographs of United States Pharmacopeia (USP):

• Metformin Hydrochloride
• Pioglitazone and Metformin Hydrochloride Tablets
• Metformin Hydrochloride Tablets
• Glyburide and Metformin Hydrochloride Tablets

생화학적/생리학적 작용

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319
• 예방조치 성명서: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable