1667508

Tobramycin

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• 실험식(Hill 표기법): C₁₈H₃₇N₅O₉
• CAS Number: 32986-56-4
• Molecular Weight: 467.51
• Beilstein: 1357507
• MDL number: MFCD00077885
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329751327
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: tobramycin
• 제조업체/상표: USP
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
• InChI key: NLVFBUXFDBBNBW-SNGYORCQSA-N

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

It is intended to be used as a USP reference standard in specified quality tests and assays.(1)
Also used to prepare the standard solution for identification and assay of tobramycin and its different dosage forms using thin-layer chromatography (TLC) and liquid chromatography (LC) combined with UV detection at 365 nm respectively, as prescribed in the United States Pharmacopeia (USP) for the following monographs:

• Tobramycin
• Tobramycin for Injection
• Tobramycin Ophthalmic Ointment
• Tobramycin Ophthalmic Solution
• Tobramycin Injection
• Tobramycin Sulfate
• Tobramycin and Dexamethasone Ophthalmic Suspension
• Tobramycin Inhalation Solution
• Tobramycin and Fluorometholone Acetate Ophthalmic Suspension
• Tobramycin and Dexamethasone Ophthalmic Ointment
  

생화학적/생리학적 작용

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361f
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable