MilliporeSigma

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Synonyms:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Species:
UniProtKB ID:
Gene ID:
  • Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
  • dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Thale Cress(818265) ABC transporter B family member 1
  • naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Small Molecule - Agonist

Product Number
Description
Species
9(10H)-Acridanone, 99%,
Species
human
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone-Water Soluble, BioReagent, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone, ≥98% (HPLC),
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
Chlorosulfonyl isocyanate, 98%,
Species
human
Ivermectin, ,
Species
mouse, human
Omeprazole, solid,
Species
human
Clotrimazole, ,
Species
mouse, human
Erythromycin, tested according to Ph. Eur.,
Species
mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ABCB1 antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
Application
immunohistochemistry
Anti-MDR1 Antibody, clone UIC2, azide free, clone UIC2, Chemicon®, from mouse,
Species Reactivity
human, primate
Application
flow cytometry
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)
Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2, clone UIC2, Chemicon®, from mouse,
Species Reactivity
human, primate
Application
flow cytometry
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Species Reactivity
hamster, human
Application
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Anti-P Glycoprotein Antibody, clone 2U4E9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot

Cell Lines

Product Number
Description
Species
SB-MDR1-HEK293, recombinant, expressed in HEK 293 cells,
Species
human
MDR1 Knockout HepaRG Cells, 1 vial,
Species
human
Kidney PTEC MDR1 KnockoutCells [MDR1 knock out (-/-)], ,
Species
human
Canine MDR1 Knockout, Human MDR1 Knockin MDCKII Cells, ,
Species
human
MDR1 Knockout Caco-2 Cells, one vial,
Species
human

Kits

Product Number
Description
Species
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Species
human, mouse, rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat
Dexamethasone, tested according to Ph. Eur.,
Species
mouse, rat, human
Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Species
mouse, rat, human
Dexamethasone, meets USP testing specifications,
Species
mouse, rat, human
Dexamethasone, ≥98% (HPLC), powder,
Species
mouse, rat, human

Proteins

Product Number
Description
Species
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Species
human
PrEST Antigen ABCB1, Prestige Antibodies® Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
PrEST Antigen ABCB1, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ABCB1,
Species
human