MilliporeSigma

CASP3

caspase 3, apoptosis-related cysteine peptidase

Synonyms:
CPP32, CPP32B, SCA-1
Species:
UniProtKB ID:
Gene ID:
  • Human(836) Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
  • Mouse(12367) caspase 3
  • Rat(25402) caspase 3
  • dog(403567) caspase 3, apoptosis-related cysteine peptidase
  • chicken(395476) caspase 3, apoptosis-related cysteine peptidase
  • naked mole-rat(101712867) caspase 3, apoptosis-related cysteine peptidase
  • domestic guinea pig(100718309) caspase 3, apoptosis-related cysteine peptidase
  • cow(408016) caspase 3, apoptosis-related cysteine peptidase
  • Domestic Rabbit(100008840) caspase 3, apoptosis-related cysteine peptidase
  • sheep(443031) caspase 3, apoptosis-related cysteine peptidase
  • domestic cat(493932) caspase 3, apoptosis-related cysteine peptidase
  • Horse(100034083) caspase 3, apoptosis-related cysteine peptidase

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Activity Assay

Product Number
Description
Species
Caspase 3 Assay Kit, Colorimetric, ,
Species
human
Caspase 3 Assay Kit, Fluorimetric, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-Caspase 3 (pSer150) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
ANTI-CLEAVED-CASP3 (ASP175) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
Anti- active + pro Caspase-3 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Caspase3 (active form) Antibody, clone 3D9.3, clone 3D9.3, from mouse,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry

western blot
Anti-Caspase-3 Antibody, clone 3J16 , ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, human, mouse, rat
Application
flow cytometry
immunocytochemistry

immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
1-Methylisatin, 97%,
Species
human
Z-VAD-FMK, solid,
Species
mouse, rat, human
N-Acetyl-Asp-Glu-Val-Asp-al, ≥95%, powder,
Species
human
NSCI, ≥97% (HPLC), solid,
Species
human

Kits

Product Number
Description
Species
CaspaTag Caspase 3,7 In Situ Assay Kit, Sulforhodamine, ,
Species
human
CaspaTag Caspase 3,7 In Situ Assay Kit, Fluorescein, The In Situ Caspase Detection Kit for Flow Cytometry use a novel approach to detect active caspases. The methodology is based on Fluorochrome Inhibitors of Caspases (FLICA).,
Species
human
CaspaTag Caspase 3,7 In Situ Assay Kit, Fluorescein, The CaspaTag Caspase-3/7 In Situ Assay Kit, Fluorescein for Flow Cytometry is a fluorescent-based assay for detection of active caspase-3 or caspase-7 in cells undergoing apoptosis.,
Species
human
Caspase 3 Colorimetric Activity Assay Kit, DEVD, Caspase-3 Colorimetric Activity Assay Kits provide a simple & convenient means for assaying the activity of caspases that recognize the sequence DEVD.,
Species
human
Caspase 3 Colorimetric Activity Assay Kit, DEVD, Caspase-3 Colorimetric Activity Assay Kits provide a simple & convenient means for assaying the activity of caspases that recognize the sequence DEVD.,
Species
human

Proteins

Product Number
Description
Species
Caspase 3 human, ≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous glycerol solution, ≥1.0 units/mg protein,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CASP3,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin, ≥90% (HPLC), powder,
Species
human
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide, ≥97% (HPLC), powder,
Species
human