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Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average MN 550, methoxy, hydroxyl

Synonym(s):

Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG

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About This Item

Linear Formula:
CH3(OCH2CH2)nOH
CAS Number:
9004-74-4
MDL number:
MFCD00084416
UNSPSC Code:
12162002
PubChem Substance ID:
24852066
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether, average Mn 550

vapor density

>1 (vs air)

vapor pressure

0.05 mmHg ( 20 °C)

form

semisolid

mol wt

average Mn 550

refractive index

n20/D 1.455

viscosity

7.5 cSt(210 °F)(lit.)

transition temp

Tm 20 °C

density

1.089 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methoxy

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Application

Poly(ethylene glycol) methyl ether can be used as a pore-forming agent to prepare polysulfone membranes with enhanced hydrophilicity.

Poly(ethylene glycol) methyl ether-grafted polyamidoamine (PAMAM) dendrimers can be used as drug carrier systems for anticancer drugs.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

359.6 °F - closed cup

flash_point_c

182 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
0000377733
0000319951
0000319951
0000377733
0000249498

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Polyethylene glycol dimethyl ether 500 (stabilised) for synthesis

Sigma-Aldrich

8.14171

Polyethylene glycol dimethyl ether 500

Jiani Zheng et al.
Langmuir : the ACS journal of surfaces and colloids, 28(37), 13261-13273 (2012-08-28)
Alginate/chitosan/alginate (ACA) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (MPEG) to improve protein repellency and biocompatibility. Increased MPEG surface graft density (n(S)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness
Lei Liu et al.
International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Hyo Won Seo et al.
Biomaterials, 34(11), 2748-2757 (2013-01-25)
The effectiveness of systemically administered anticancer treatments is limited by difficulties in achieving therapeutic doses within tumors, a problem that is complicated by dose-limiting side effects to normal tissue. To increase the efficacy and reduce the toxicity of systemically administered
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Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

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