269107

L-tert-Leucine

99%, for peptide synthesis

• Synonym(s): (S)-2-Amino-3,3-dimethylbutyric acid, L-α-tert-Butylglycine
• Linear Formula: (CH₃)₃CCH(NH₂)CO₂H
• CAS Number: 20859-02-3
• Molecular Weight: 131.17
• Beilstein/REAXYS Number: 1721824
• MDL number: MFCD00064218
• UNSPSC Code: 12352209
• PubChem Substance ID: 24856311
• NACRES: NA.22

Properties

• product name: L-tert-Leucine, 99%
• assay: 99%
• form: powder
• optical activity: [α]20/D −9.5°, c = 3 in H₂O
• optical purity: ee: 99% (GLC)
• reaction suitability: reaction type: solution phase peptide synthesis
• mp: ≥300 °C (lit.)
• application(s): peptide synthesis
• SMILES string: CC(C)(C)[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-6(2,3)4(7)5(8)9/h4H,7H2,1-3H3,(H,8,9)/t4-/m1/s1
• InChI key: NPDBDJFLKKQMCM-SCSAIBSYSA-N

Description

General description

L-tert-Leucine is an amino acid used as a precursor for synthesizing chiral tridentate Schiff base ligands.

Application

L-tert-Leucine can be used:

• As a key precursor in the synthesis of a chiral phosphinooxazoline ligand, (S)-tert-butylPHOX.
• In the synthesis of chiral copper(II) polymers that can catalyze the kinetic resolution of secondary alcohols by acylation.
• In metal-free tandem radical cyclization reactions to synthesize 6-alkyl/acyl phenanthridines.
• In the preparation of tert-leucine-derived N-acetylthiazolidinethione auxiliary that provides high levels of diastereoselection in acetate aldol reactions with a variety of aldehydes.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)