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809608

Sigma-Aldrich

Biotin-2′,2′,3′,3′-d4

≥98 atom % D, ≥95% (CP)

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Synonym(s):
Vitamin B7-d4, Vitamin B8-d4, Vitamin H-d4
Empirical Formula (Hill Notation):
C10D4H12N2O3S
Molecular Weight:
248.34
PubChem Substance ID:
NACRES:
NA.12

isotopic purity

≥98 atom % D

Quality Level

assay

≥95% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

color

white to off-white

mp

228 °C

mass shift

M+4

storage temp.

−20°C

SMILES string

OC(CC([2H])([2H])C([2H])([2H])C[C@@H]1SC[C@@]2([H])[C@]1([H])NC(N2)=O)=O

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1/i1D2,2D2

InChI key

YBJHBAHKTGYVGT-CCSQOTJNSA-N

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1 of 4

This Item
70526816582B1116000
vibrant-m

809608

Biotin-2′,2′,3′,3′-d4

vibrant-m

705268

Biotin-(ring-6,6-d2)

vibrant-m

B1116000

Biotin

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

-

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

mass shift

M+4

mass shift

M+2

mass shift

-

mass shift

-

isotopic purity

≥98 atom % D

isotopic purity

≥98 atom % D

isotopic purity

-

isotopic purity

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

General description

Biotin is a water-soluble vitamin B which is also known as vitamin B7. It is involved in the synthesis of fatty acids and gluconeogenesis. Biotin is found in plants and animals. Its deficiency causes retardation in growth, alopecia and neurological impairment in humans and animals.
Biotin-2′,2′,3′,3′-d4 is an isotope of vitamin B7 wherein C-2′, C-2′, C-3′, C-3′ protons are replaced by deuterium.

Application

Biotin-2′,2′,3′,3′-d4 can be used as a stable isotope internal standard for accurate data interpretation in specific biological samples.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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A IJpelaar et al.
Clinical biochemistry, 83, 78-80 (2020-05-31)
Despite the increasing awareness about biotin interference with immunoassays, so far, only two studies have quantified the prevalence of elevated biotin in patient populations. In a US study, over 7% had biotin concentrations exceeding 10 ng/mL, whereas in an Australian study
Agar plate method using Lactobacillus plantarum for biotin determination in serum and urine
FUKUI T, et al.
J. Nutr. Sci. Vitaminol., 40(5), 491-498 (1994)
Factitious Graves disease due to biotin immunoassay interference-a case and review of the literature
Elston MS, et al.
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Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature
Cyran CC, et al.
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